Isolated vitreoretinal amyloidosis in the absence of transthyretin mutations.

(along with her daughter) systemic symptoms characteristic of coxsackievirus infection preceding her visual symptoms. However, the acute and convalescent coxsackievirus antibody titers that were obtained in the woman were not abnormal. There have been several reports of coxsackievirus infection associated with chorioretinitis, and the lesions described bear some resemblance to UAIM. Coxsackievirus A16 and less commonly coxsackie variants A2, A5, A7, A9, A10, B1, B2, B3, B4, B6, and enterovirus 71 are generally responsible for hand-foot-andmouth disease. Clinical interpretation of complement fixation test results for coxsackievirus ideally requires comparison of a short-term serum sample with a convalescent serum sample. In our first patient, although only convalescent serum samples were obtained, the level of coxsackievirus A16 and B6 antibodies was elevated. The second case of hand-foot-and-mouth disease was diagnosed clinically based on the presence of the classic physical findings that defined the disease in the patient and his 2 children. The temporal relationship between the onset of hand-footand-mouth disease and the development of retinal findings consistent with UAIM suggests that they may be related. Heightened awareness of this possible relationship should prompt retinal specialists to obtain acute and convalescent coxsackievirus antibody titers so that we can determine whether UAIM should be renamed “coxsackievirus maculopathy.”